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Cornea: Fundamentals, Diagnosis and Management
Authors:  Jay H. Krachmer, MD, Mark J. Mannis, MD, FACS and Edward J. Holland, MD
Pages:  2080  Two Volume Hard Cover Set  with DVD and Expert Consult online content
ISBN 13:
Saunders/ Elsevier   2011
List Price:  $359

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MedicalScienceBooks.com Medical Book Review:

     At first glance the cornea seems to be a relatively straightforward and simple component of ocular anatomy.  In actuality there are a host of factors that make this tissue a highly complex entity with a variety of vulnerabilities to congenital defect, infection and trauma.  Cornea:  Fundamentals, Diagnosis and Management 3rd Edition remains one of the few core texts that manages to provide a comprehensive and authoritative collection of evidence-based clinical knowledge regarding the cornea and supporting structures written by an international team of experts. 
     One of the defining features of success with a project of this large scale is the foresight by the editors in evaluating the current literature and identifying a well-defined role that their publication will fill in clinics around the world.  Corneal pathologies are at the forefront of patient management issues encountered by the eye care team.  There is certainly a place for focused monographs on specific conditions or surgical procedures of the cornea on the reference shelf of any practicing ophthalmologist.  However, the ability to have an in-depth survey of all the major topics in corneal structure, physiology and medical/surgical treatment within one publication is invaluable as a reference tool. Even when we consider the transition from textbook and journal reading to electronic database searching and mobile reading devices, as the editors have in the preface, there is still a dire need for the organization and presentation of information that is part of the traditional publication process.  Every field of medicine requires this “repository” of its most important tenets and progress to the current time and Cornea 3rd edition clearly fills this role for Ophthalmology along with a handful of other titles.
     The editorial team, which has remained intact from the previous edition, has once again done an exceptional job of keeping pace with the expanding basic science and technological research in ophthalmology.  Perhaps of even greater importance to the success of the book than including the latest topics in the field is choosing the most appropriate author for each chapter which is another mark of accomplishment for this text.  The first volume of this two- volume set details the basic science foundation of corneal structure and functions as well as the medical management of disease.  There are many excellent chapters in this volume which could easily form the basis of short monographs on their own merit. Among these standout chapters, the ones describing imaging techniques will have a special appeal to those readers who are familiarizing themselves with the key equipment necessary for clinical ophthalmology.  The many color photographs both taken with digital camera and with scope technology complement and add to the diagnostic value of the text.  Other chapters detailing anterior uveitis are also particularly well written.
     The second volume is dedicated to surgical management approaches to the cornea.  Hot topics in this area including laser vision correction and ocular surface transplantation are expertly covered, again with high quality photographs and illustrations.  An excellent companion to the text which was introduced with the 2nd edition of this title is a DVD ROM with video clips of the various surgeries described in the chapters.  The ability to visualize these techniques in the dynamic condition rather than static pictures makes for an even better introduction to, or review of, the key aspects and potential pitfalls associated with corneal surgery.
     As a comprehensive treatise on corneal and associated structure disease and surgery, Cornea 3rd edition is at the front of its class.  No other comparable publications have quite achieved the same balance of comprehensiveness and clinical relevance with additional online and DVD content.  It is recommended that all medical libraries, ophthalmology departments and eye specialists have a copy of this book close at hand and refer to it often to the benefit of their patients.

Ratings (1-4 , 4 being the highest):

Organization of information:    4

Usefulness of book:     4

Suitable for intended audience:    4

Author’s objectives met:      4

Significant number of illustrations:     4

Quality of illustrations:    4


Cornea, edited by Drs. Krachmer, Mannis & Holland, is the only truly comprehensive clinical reference available that covers external disease, anterior uveitis, and the expanding range of contemporary corneal surgery. In this Third Edition, state-of-the-art coverage, 25 brand-new chapters, and 45 new videos provide expert guidance on performing femtosecond-assisted penetrating keratoplasty, DSAEK, deep anterior lamellar keratoplasty, and many other cutting-edge techniques. Plus, you'll have easy access to the complete contents and illustrations online at expertconsult.

Key Features:

  • Overcome any clinical challenge related to the cornea, external disease, anterior uveitis, and the expanding range of contemporary corneal surgery with the most complete, authoritative guidance source available.
  • Get superb visual guidance with exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs.

What's New to this edition?:

  • Access the complete contents and illustrations online at expertconsult.
  • Make optimal use of Anterior Segment OCT to plan and choose treatment options and assess post-operative recovery.
  • Master the latest surgical techniques-including femtosecond-assisted penetrating keratoplasty, DSAEK, and deep anterior lamellar keratoplasty-thanks to 25 brand-new chapters and 45 new videos on DVD (a total of 3 hours running time).
  • Understand the full spectrum of corneal diseases with coverage of the new corneal dystrophy classification that incoporates current genetic, clinical, and pathologic information.

Table of Contents:


Volume I: Fundamentals and Medical Aspects of Cornea and External Disease

Part I: Basic Science: Cornea, Sclera, Ocular Adnexa Anatomy, Physiology and Pathophysiologic Responses

1. Cornea and Sclera: Anatomy and Physiology
2. The Conjunctiva: Anatomy and Physiology
3. Tear Film
4. The Eyelids
5. A Matrix of Pathologic Responses in the Cornea

Part II: Examining and Imaging the Cornea and External Eye

Section 1: Basic Evaluation of the Cornea and External Eye

6. Examination of the Lids
7. Slit Lamp Examination and Photography
8. Tear Film Evaluation
9. Refraction of the Abnormal Cornea
10. Corneal Diagnostic Techniques

Section 2: Laboratory Investigations

11. Practical Opthalmic Microbiology for the Detection of Corneal Pathogens
12. Molecular Genetics of Corneal Disease

Section 3: Imaging Techniques of the Cornea

13. Keratometry and Topography
14. Specular Microscopy
15. Confocal Microscopy
16. High-Resolution Ultrasound
17. Anterior Segment Optical Coherence Tomography

Part III: Differential Diagnosis of Selected Problems in Corneal and External Eye Disease

18. Congenital Corneal Opacities: Diagnosis and Management
19. Peripheral Corneal Disease
20. The Corneal Ulcer
21. Corneal Edema
22. Corneal Deposits
23. Corneal Infiltrates in the Contact Lens Patient
24. The Red Eye
25. Minimal Visual Loss: Determining the Role of the Cornea
26. The Approach to a Patient with Itching and Burning

Part IV: Eye Banking

27. Eye Banking: Structure and Function
28. Medical Standards for Eye Banking

Part V: The Ocular Adnexa

Section 1: Diseases of the Lid: Anatomic Abnormalities

29. Eyelid Disorders: Entropion, Ectropion, Trichiasis, and Distichiasis
30. Lagophthalmos and Other Malpositions of the Lid

Section 2: Diseases of the Lid: Tumors

31. Benign Lid Tumors
32. Malignant Eyelid Tumors

Section 3: Diseases of the Lid: Inflammation and Infections

33. Blepharitis: Overview and Classification
34. Meibomian Gland Dysfunction and Seborrhea
35. Eyelid Infections

Section 4: Disorders of Tear Production and Lacrimal System

36. Dry Eye
37. Dacryoadenitis, Dacryocystitis, and Canaliculitis
38. Epiphora

Part VI: The Conjunctiva

Section 1: Conjunctival Disease: Tumors

39. Squamous Neoplasms of the Conjunctiva
40. Melanocytic Neoplasms of the Conjunctiva
41. Subepithelial Neoplasms of the Conjunctiva

Section 2: Conjunctivitis

42. Conjunctivitis: An Overview and Classification
43. Bacterial Conjunctivitis
44. Viral Conjunctivitis
45. Chlamydial Infections
46. Opthalmia Neonatorum
47. Parinaud's Oculoglandular Syndrome
48. Seasonal and Perennial Allergic Conjunctivitis
49. Vernal and Atopic Keratoconjunctivitis
50. Giant Papillary Conjunctivitis
51. Cicatricial Pemphigoid
52. Erythema Multiforme, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
53. Toxic Conjunctivitis
54. Superior Limbic Keratoconjunctivitis
55. Ligneous Conjunctivitis
56. Conjunctivochalasis

Part VII: Diseases of the Cornea

Section 1: Developmental Abnormalities of Cornea

57. Developmental Corneal Anomalies of Size and Shape
58. Axenfeld-Rieger Syndrome and Peters' Anomaly

Section 2: Corneal Manifestations of Systemic Disease and Therapies

59. Corneal Manifestations of Metabolic Diseases
60. Skeletal and Connective Tissue Disorders with Anterior Segment Manifestations
61. Inflammatory Bowel Disease and Other Systemic Inflammatory Diseases
62. Nutritional Disorders
63. Hematologic Disorders
64. Endocrine Disease and the Cornea
65. Dermatologic Disorders and the Cornea
66. Infectious Disease: Corneal Manifestations
67. Corneal and External Ocular Infections in Acquired Immunodeficiency Syndrome (AIDS)
68. Ocular Graft-versus-Host Disease
69. Corneal Manifestations of Local and Systemic Therapies

Section 3: Corneal Dystrophies, Ectatic Disorders, and Degenerations

70. Corneal Dystrophy Classification
71. Anterior Corneal Dystrophies
72. The Stromal Dystrophies
73. Descemet's Membrane and Endothelial Dystrophies
74. Noninflammatory Ectatic Disorders
75. Iridocorneal Endothelial Syndrome
76. Corneal and Conjunctival Degenerations

Section 4: Corneal Infections

77. Bacterial Keratitis
78. Nontuberculous Mycobacteria Keratitis
79. Herpes Simplex Keratitis
80. Herpes Zoster Keratitis
81. Less Common Viral Corneal Infections
82. Fungal Keratitis
83. Acanthamoeba and Other Parasitic Corneal Infections
84. Corneal Diseases in the Developing World

Section 5: Interstitial Keratitis

85. Syphilitic Stromal Keratitis
86. Nonsyphilitic Interstitial Keratitis

Section 6: Noninfectious Keratopathy

87. Corneal Micropuncture in Recurrent Erosion Syndromes
88. Filamentary Keratitis
89. Thygenson's Superficial Punctate Keratitis
90. Neurotrophic Keratitis
91. Factitious Keratoconjunctivitis

Section 7: Immunologic Disorders of the Cornea

92. Corneal Disease in Rheumatoid Arthritis
93. Corneal Disease Associated with Nonrheumatoid Collagen-Vascular Disease
94. Phlyctenular Keratoconjunctivitis and Mariginal Staphylococcal Keratitis
95. Mooren's Ulcer

Section 8: Corneal Trauma

96. Corneal Complications of Intraocular Surgery
97. Mechanical Injury
98. Acid Injuries of the eye
99. Alkali Injuries of the Eye
100. External Eye Manifestations of Biological and Chemical Warfare

Section 9: Contact Lenses

101. Contact Lens Applications in Corneal Disease
102. Complications of Contact Lens Wear

Part VIII: The Sclera and Anterior Uvea

Section 1: Disorders of the Sclera

103. Episcleritis
104. Scleritis

Section 2: Anterior Uveitis

105. Classification and Diagnosis of Anterior Uveitis
106. Idiopathic Uveitis
107. HLA-B27-Related Uveitis
108. Sarcoidosis
109. Behcet's Disease
110. Fuch's Heterochromic Iridocyclitis
111. Juvenile Idiopathic Arthritis


Volume II: Surgery of teh Cornea and Conjunctiva

Part IX: Keratoplasty

Section 1: Overview

112. The Evolution of Contemporary Keratoplasty
113. Preoperative Considerations and Decision-Making in Keratoplasty

Section 2. Penetrating Keratoplasty Procedures

114. Penetrating Keratoplasty
115. Pemtosecond Laser-assisted Penetrating Keratoplasty
116. Keratoplasty Suturing Techniques
117. Intraoperative Complications of Penetrating Keratoplasty

Section 3: Penetrating Keratoplasty: Postoperative Management

118. Routine Management
119. Early Postoperative Complications
120. Management of Postkeratoplasty Astigmatism
121. Diagnosis and Management of Corneal Allograft Rejection
122. Infections after Penetrating Keratoplasty
123. Retrocorneal Membranes
124. Glaucoma after Penetrating Keratoplasty

Section 4: Complex Penetrating Keratoplasty

125. Pediatric Penetrating Keratoplasty
126. Large-Diameter Corneal Grafts
127. Penetrating Keratoplasty in Herpes Simplex Disease
128. Immunologically High-Risk Penetrating Keratoplasty

Section 5: Anterior Lamellar Keratoplasty

129. Indications for Anterior Lamellar Keratoplasty
130. Techniques for Anterior Lamellar Keratoplasty
131. Intraoperative and Postoperative Complications of Anterior Lamellar Keratoplasty
132. Outcomes of Anterior Lamellar Keratoplasty

Section 6: Endothelial Keratoplasty

133. Indications for Endothelial Keratoplasty
134. Donor Preparation for Endothelial Keratoplasty
135. Surgical Techniques of Endothelial Keratoplasty
136. Phacoemulsification and Endothelial Keratoplasty: the New Triple Procedure
137. Intraoperative and Postoperative Complications of Endothelial Keratoplasty
138. Outcomes of Endothelial Keratoplasty

Part X: Therapeutic Procedures

Section 1: Corneal Surgery

139. Management of Corneal Perforations
140. Therapeutic Lamellar Keratoplasty
141. Therapeutic Keratoplasty
142. Surgical Management of Superficial Corneal and Conjunctival Disease
143. Excimer Laser Phototherapeutic Keratoctomy

Section 2: Conjunctival Surgery

144. Mangement o fPteryglum
145. Conjunctival Flaps
146. Indications for and Uses of Amniotic Membrane

Section 3: Anterior Segment Surgery

147. Surgical Management and Rehabilitation of Anterior Segment Trauma
148. Iris Reconstruction Surgery
149. Management of Scleral Perforation

Part XI: Keratoprosthesis

150. Indications for Keratoprosthesis
151. Types and Techniques of Keratoprosthesis
152. Postoperative Management of Keratoprosthesis
153. Outcome of Keratoprosthesis Surgery

Part XII: Ocular Surface Transplantation

154. Classification and Staging of Ocular Surface Disease
155. Surgical Techniques for Ocular Surface Reconstruction
156. Postoperative Management of Ocular Surface Reconstruction
157. Corneal Transplantation in Ocular Surface Disease

Part XIII: Refractive Surgery

Section 1: Preoperative Considerations

158. Decision Making in Refractive Surgery
159. Patient Evaluation and Selection in Refractive Surgery
160. Topographic Analysis in Keratorefractive Surgery

Section 2: Laser Vision Correction

161. Excimer Laser Surface Treatment : Photorefractive Keratectomy
162. LASIK Technique
163. LASIK for Myopia
164. LASIK for Hyperopia
165. Surface Ablation: Techniques for Managing the Epithelial Layer
166. LAIK Complications
167. Corneal Ectasia: Prevention and Detection
168. Corneal Ectasia: Management

Section 3: Intrastromal Corneal Ring Segments

169. Intrastromal Corneal Ring Segments

Section 4: Incisional Keratotomy

170. Incisional Keratotomy

Section 5: Phakic Myopic Intraocular Lenses

171. Phakic Myopic Intraocular Lenses


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