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Infectious Diseases, 3rd Edition Two-Volume Set with Expert Consult
Authors:  Jonathan Cohen, M Sc, FRCP, FRCPath, FRCPE, FMedSci, William G. Powderly, MD and Steven M. Opal, MD
Pages:  2070  Two Volume Hard Cover Set
ISBN 13:
Mosby/ Elsevier   2011

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Medical Science Books .com  Medical Book Review:

     Recent advances in the techniques associated with molecular biology and genetic analysis have contributed greatly to our ever-expanding knowledge base regarding diagnosis and treatment of infectious disease.  Infectious Diseases 3rd Edition stands at the forefront of publications in its class.  Clinical professionals are presented a balanced view of both relevant basic science progress and its translation into patient management of a comprehensive list of infectious diseases. Although this may seem to be the basis on which at least a dozen other publications on the market were constructed upon, there are some important differences which make Infectious Diseases 3rd Edition a clear choice for many individuals in need of a survey of the infectious disease field.
     Medical students and physicians, who have spent a good deal of time in their training learning about microorganisms, often have a preference as to how this information is presented.  Traditionally, medical microbiology courses have used the “bug parade” approach in which organisms are presented based on their category (bacteria, virus, etc..) and then further subdivided based on physical characteristics, family, etc.  Over the past decade or so, many medical curricula have turned to an integrated system in which microbes are presented in relation to the organ system in which they cause major disease.  This text caters to both types of presentation style giving readers maximum flexibility as to how they wish to learn and review this material.  Section 2 contains an excellent review of infectious disease by body system and Section 8 entitled Clinical Microbiology falls more within the lines of the “bug parade” approach.  The benefit of presenting this information in both styles within the same text is the invaluable learning exercise of being able to correlate specific information regarding a microorganism with a clinical syndrome without having to consult a variety of sources which typically choose one style over the other. 
     Adding to the clinical utility of the text, and fulfilling the editors’ purpose of providing a concise clinical resource, are “Practice Point” sections that are included throughout the book in support of commonly encountered issues or dilemmas in patient management.  These sections offer highly focused and evidence-based guidelines that will serve the reader well in developing their own approach to similar situations.  In addition to the clinical information, many of the practice point sections also include an array of full color clinical photographs to aid in identification of disease pathology.  Color photographs and clearly drawn illustrations are also found liberally distributed throughout the text with particularly useful photographs of a variety of disease vector and parasitic organisms. 
     Infectious Diseases 3rd Edition is highly recommended as a reference to keep close at hand for infectious disease specialists and general physicians.  Medical students will also benefit greatly from this text if they are willing to put the time into studying it as this is not written in the typical “high yield” genre which students have come to rely on for quick information sources.  Readers of past editions will be pleased with the additional online resources that now come with this Expert Consult edition.


Ratings (1-4 , 4 being the highest):

Organization of information:    4

Usefulness of book:     3

Suitable for intended audience:    4

Author’s objectives met:      4

Significant number of illustrations:     3.5

Quality of illustrations:    4


Infectious Diseases, 3rd edition by Jonathan Cohen, MB, BS, FRCP, FRCPath, FRCPE, FMedSci, William G. Powderly, MD, FRCPI, and Steven M. Opal MD, provides comprehensive, practical, highly visual guidance to help you effectively overcome the latest clinical infectious disease challenges. The comprehensively updated 3rd Edition features brand-new information on new strains of the swine (H1N1) and avian influenza viruses, SARS, nosocomial infections, HIV/AIDS, and many other timely topics. Online access at expertconsult.com lets you reference the complete contents from any computer.

Key Features:

    • Find a diagnosis quickly with the popular Diseases by Body System Section.

    Stay well informed with expanded and updated coverage of nonsocomial infections and much more.

    • Access the full text contents of the entire 2-volume set online with a fully searchable website with case studies (ideal tool for learning and review for the Boards), ID secret of the week, regular content updates, disease outbreak maps, Diagnosis algorithms, downloadable image library and updates from the Lancet Infectious Disease.

    Receive unparalleled visual guidance from hundreds of full-color photographs and figures.

    Quickly search information with a consistent chapter organization and colorful page layouts.

    Get clinically-focused guidance from "Practice Points" which demonstrate how to diagnose and treat complicated problems encountered in practice.

    • Make effective diagnoses with a more efficient approach to differential diagnosis-discussions of conditions are presented in proportion to their incidence.

    Gain a more international view from editors and authors, patient photographs, and treatment perspectives from around the world.

What's New In This Edition?

Stay current with the very latest information about newly recognized infectious diseases including new strains of the swine (H1N1) and avian influenza viruses, and SARS∦many new chapters including parvoviruses, acute meningitis, chronic meningitis, GI infection, tuberculosis of the urogenital tract, approaches to acute fever and fever of unknown origin, infections in burn, surgery and trauma, immunodeficiencies and principles of infection in the immunocompromised patient, opportunistic and systemic fungi, and subcutaneous and superficial fungal pathogens.

Efficiently reference information with no overlap thanks to newly reorganized chapters including a completely refocused section on tropical and travel medicine.

Find answers quickly and easily access references with a new more streamlined, portable, and economical format. All bibliographical citations have been removed from the printed reference - allowing the two volumes to be lighter and more compact - but remain online at expertconsult.com for rapid searchability.

Get a fresh perspective from seven new section editors added to this edition, as well as an even more geographically diverse set of contributors.


Table of Contents:


Section 1:  Introduction to Infectious Diseases

1.       Nature and pathogenicity of micro-organisms

2.       Host responses to infection

3.       Vaccines and vaccination

4.       Emerging and re-emerging pathogens

5.       Mathematical models in infectious disease

6.       History of infection prevention and control

7.       Bacterial genomes

PP1  Health consequences of a changing climate


Section 2:  Syndromes by Body System




8.        Viral exanthems

9.       Cellulitis, pyoderma, abscesses and other skin and subcutaneous infections

10.    Necrotizing fasciitis, gas gangrene, myositis, and myonecrosis

11.    Arthropods and ectoparasites

12.    Dermatologic manifestations of systemic infections

13.    Superficial fungal infections

PP2  Approach to the acutely febrile patient who has a generalized rash

PP3  Management of foot ulcer

PP4  Managing the patient with recurring skin infections




14.     Lymphadenopathy

PPI5  Evaluation and management of the solitary enlarged lymph node




15.     Conjunctivitis, keratitis and infections of periorbital structures

16.    Endophthalmitis

17.    Infectious retinitis and uveitis

PPI6  Management of red eye




18.     Acute and chronic meningitis

19.    Encephalitis and myelitis

20.    Brain abscess and other focal pyogenic infections of the central nervous system

21.    Tetanus and botulism

22.    Prion diseases of humans and animals

23.    Infections in hydrocephalus shunts

PP7  When to do a lumbar puncture for the evaluation of meningoencephalitis

PP8  Approach to the patient who has fever and headache

PP9  Empiric antimicrobial therapy for suspected infection of the central nervous system




24.     Laryngitis, epiglottitis and pharyngitis

25.    Otitis, sinusitis and related conditions

26.    Bronchitis, bronchiectasis and cystic fibrosis

27.    Community-acquired pneumonia

28.    Hospital-acquired pneumonia

29.    Lung abscesses and pleural abscesses

30.    Tuberculosis and other mycobacterial infections

31.    Fungal pneumonias

PP10  Investigation of pleural discharge/fluid

PP11  Managing a postoperative fever

PP12  Use of antibiotics in common respiratory infections

PP13  When to use corticosteroids in noncentral nervous system tuberculosis

PP14  How to manage a patient on anti-TB therapy with abnormal liver enzymes

PP15  Management of the infected cystic fibrosis patient

PP16  Diagnosis and management of ventilator-associated pneumonia




32.     Orocervical infection

33.    Gastritis, peptic ulceration and related conditions

34.    Food-borne diarrheal illness

35.    Acute diarrhea

36.    Chronic diarrhea

37.    Intra-abdominal sepsis, peritonitis and pancreatitis

38.    Viral hepatitis

39.    Hepatobiliary and splenic infection

PP17  Traveler’s Diarrhea

PP18  Management of persistent postinfectious diarrhea in adults

PP19  Approach to liver abscesses




40.     Infective and reactive arthritis

41.    Acute and chronic osteomyelitis

42.    Infections of prosthetic joints and other related problems

43.    Lyme disease

PP20  Postoperative infections in a patient with a prosthetic joint




44.     Sepsis

45.    Infections associated with intravascular lines, grafts and devices

46.    Myocarditis and pericarditis

47.    Endocarditis and endarteritis

48.    Rheumatic fever

PP21  Nuclear medicine scanning

PP22 Approach to the patient with persistent bacteremia




49.     Vaginitis, vulvitis, cervicitis and cutaneous vulval lesions

50.    Infections of the female pelvis including septic abortion

51.    Complications of pregnancy: maternal perspectives

52.    Implications for the fetus of maternal infections in pregnancy

PP23  Management of an HIV-positive pregnant woman with a positive VDRL test from an area endemic for Treponema infection

PP24  Treatment of a positive Toxoplasma titer in pregnancy

PP25  A pregnant patient with a previous pregnancy complicated by group B streptococcal disease in the infant




53.     Cystitis and urethral syndromes

54.    Prostatitis, epidydimitis and orchitis

55.    Pyleonephritis and abscesses of the kidney

56.    Complicated urinary infection, including postsurgical and catheter-related infections

PP26  Management of persistent symptoms of prostatitis

PP27  Tuberculosis of the urogenital tract

PP28  Urinary tract infections in kidney transplant recipients




57.     Syphilis

58.    Genital herpes

59.    Papillomavirus infections

60.    Lymphogranuloma venereum, chancroid and granuloma inguinale

PP29  Management of gonorrhea

PP30  Persistent/recurrent vaginal discharge

PP31  Persistent or recurrent nongonococcal urethritis in men and woman


Section 3:  Special Problems in Infectious Disease Practice


61.     Pathogenesis of fever

62.    Clinical approach to the acute fever

63.    Fever of unknown origin

64.    The potential role of infectious agents in diseases of unknown etiology

65.    Infectious complications following surgery and trauma

66.    Recreational infections

67.    Occupational infections

68.    Infections from pets

69.    Infections acquired from animals other than pets

70.    Chronic fatigue syndrome

71.    Bioterrorism and biodefense

PP32  Management of Candiduria in the ICU

PP33  Infections associated with near drowning

PP34  Management of human bites

PP35  Factitious fever

PP36  Methicillin-Resistant Staphylococcus aureus (MRSA) colonization

PP37  Infection in burns

PP38  Transfusion related infections

PP39  Kawasaki disease


Section 4:  Infections in the Immunocompromised Host


72.     Immunodeficiencies

73.    Infections in the neutropenic cancer patient

74.    Infections in hematopoietic stem cell transplant recipients

75.    Infection in solid organ transplantation

76.    Heart, lung and heart-lung transplantation

77.    Liver transplantation

78.    Pancreatic transplantation

79.    Intestinal transplantation

80.    Kidney transplant patients

81.    Vasculitis and other immunologically related diseases

82.    Splenectomy and splenic dysfunction

83.    Vaccination of the immunocompromised patient

PP40  Immunodeficiencies  associated with immunosuppressive patients

PP41  Preventing tuberculosis and other serious infections in patients starting anti-tumor necrosis factor therapy

PP42  Infectious diseases transmitted by grafts

PP43  BK virus replication and disease in transplant patients




Section 5:  HIV and AIDS


84.     Epidemiology of HIV infection




85.     Prevention of HIV transmission through behavioral change and sexual means

86.    Preventing occupational HIV infection in the health-care environment

87.    HIV vaccines:  Past failures and future scientific challenges


88.     The immunopathogenesis of HIV-1


89.     Primary HIV infection

90.    Prevention of opportunistic infections

91.    Opportunistic infections

92.    Disorders of immune reconstitution in patients with HIV infection

93.    Tuberculosis in HIV

94.    Neoplastic disease

95.    Dermatologic manifestations of HIV infection

96.    HIV/AIDS-related problems in developing countries

PP44  Hepatitis B in the HIV co-infected patient




97.     HIV infection in children

98.    Special problems in women who have HIV disease


99.     Principles of management of HIV in the developed world

100.Antiviral therapy

PP45  Drug interactions in HIV and AIDS

PP46  How to manage the hepatitis C virus co-infected HIV patient

PP47  How to manage hyperlipidemia in the HIV patient

PP48  Multidrug resistant HIV


Section 6:  International Medicine


101. Geography of infectious diseases

102.Pretravel advice and immunization

PP49  Fever in a returned traveler from Kenya or the Congo

PP50  Skin rashes in a returned traveler from Ecuador

PP51  Jaundice in a returned traveler from Nepal

PP52  Sexually transmitted infection in a returned traveler from Durban

PP53  Eosinophilia in a returned traveler from West Africa

PP54  Lymphadenopathy, splenomegaly and anemia in a returned traveler from Sudan

PP55  History of an animal bite in a returned traveler from Burma




103. Leprosy

104.Endemic treponematoses


105.  African trypanosomiasis

106.  Other parasitic infections of the central nervous system

107.  Eye infections in the tropics

PP56  Managing an outbreak of meningococcal disease in and African village




108. Parasitic infections of the gastrointestinal tract

109.  Typhoid fever and other enteric fevers

110.  Amebic infections

PP57  Diarrhea in a returned traveler from Mexico

PP58  Amebic cysts in the stool




111. Malaria

112.  Schistosomiasis

113.  Cestode and trematode infections

114.  Hydatid disease

115.  Filariasis

116.  Infections in sickle-cell disease

117.  Leishmaniasis

118.  Chagas disease  (American Trypanosomiasis)

119.  Melioidosis

120.  Plague

121.  Tularemia

122.  Scrub typhus and other tropical rickettsioses

123.  Brucellosis

124.  Leptospirosis

125.  Relapsing fevers

126.  Viral hemmorrhagic fevers

127.  Dengue

128.  Anthrax

PP59  What are the treatment options for a pregnant patient with malaria?

PP60  Management of a patient from Gabon with fever, malaise, sore throat and a negative malaria smear

PP61  Follow-up of the returned traveler who has swum in Lake Malawi


Section 7:  Anti-Infective Therapy


129. Principles of anti-infective therapy

130.  Mechanisms of action

131.  Mechanisms of antibacterial resistance

132.  Antibiotic prophylaxis

133.  Non-inpatient parenteral antimicrobial therapy

134.  β-lactam antibiotics

135.  Macrolides, ketolides, lincosamides and streptogramins

136.  Oxazolidinones

137.  Aminoglycosides

138.  Folate inhibitors

139.  Quinolones

140.  Glycopeptides

141.  Tetracycline and chloramphenicol

142.  Nitroimidazoles:  metronidazole, ornidazole and tinidazole

143.  Antituberculosis agents

144.  Miscellaneous agents:  Fusidic acid

145.  Antiretroviral agents

146.  Drugs for herpesvirus infection

147.  Antiviral agents against respiratory viruses

148.  Drugs to treat viral hepatitis

149.  Antifungal agents

150.  Antiparasitic agents

Section 8:  Clinical Microbiology


151. Acute gastroenteritis viruses

152.  Measles, mumps and rubella viruses

153.  Human enteroviruses

154.  Hepatitis viruses

155.  Herpesviruses

156.  Papillomaviruses

157.  Polyomaviruses

158.  Parvoviruses

159.  Poxviruses

160.  Rabies and rabies-related viruses

161.  Influenza viruses

162.  Respiratry viruses

163.  Retroviruses and retroviral infections

164.  Zoonotic viruses


165. Staphylococci and micrococci

166.  Streptococci, enterococci and other catalase-negative cocci

167.  Aerobic Gram-positive bacilli

168.  Neisseria

169.  Enterobacteriaceae

170.  Pseudomonas spp., Acinetobacter spp., and miscellaneous Gram-negative bacilli

171.  Curved and spiral bacilli

172.  Gram-negative coccobacilli

173.  Anaerobic bacteria

174.  Mycobacteria

175.  Mycoplasma and Ureaplasma

176.  Rickettsia and rickettsia-like organisms

177.  Chlamydia


178. Opportunistic and systemic fungi

179.  Superficial and subcutaneous fungal pathogens




180.  Protozoa:  intestinal and urogenital amebae, flagellates and ciliates

181.  Protozoa:  intestinal coccidian and microsporidia

182.  Protozoa:  free-living amebae

183.  Blood and tissue protozoa

184.  Helminths

INDEX to Volumes 1 and 2

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