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Molecular Mechanisms of Neurotransmitter Release
Author: Wang, Zhao-Wen
Hard Cover w/cd rom
Pages: 340   2009
ISBN-13: 978-1-934115-38-1
List Price $149
Humana Press

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Medical Science Books Medical Book Review:

Molecular Mechanisms of Neurotransmitter Release edited by Zhao-Wen Wang provides the reader with a comprehensive overview of the complex interactions occurring in pre-synaptic neurons involved with chemical communication.  Each chapter comprises a stand-alone monograph written by experts in the field focusing on different aspects of neurotransmitter release.  Although synaptic junction research is an exceptionally prolific area of research and new studies are published weekly, the topics included in this volume represent a solid core of knowledge upon which further investigations of neurotransmission continue to build.

     In spite of the contributions from over 25 authors, a relatively consistent writing style was maintained throughout.  Refreshingly, for a research science title, that style includes clear explanation and the elimination of jargon and abbreviations which donít increase understanding. This makes the material highly approachable even by a student with a limited background in neuroscience but an interest in the subject material.  Clarity of style is also not wasted on the active neuroscientist who may only have expertise in one area discussed in the text but requires a more rounded view of all the pertinent processes that are involved in axonal release of neurotransmitters. High quality illustrations, a large number of which are in full color, support the information in the text and are also available on a companion CD-ROM that is packaged with the book.

     This book is recommended for the researcher and student of neuroscience alike.  Clinical professionals often donít have time to delve into physiology texts due to strict time constraints, but Neurology residents undergoing specialty training in neuromuscular disease will find this book to be an invaluable resource. 

Joseph Vito Russo, MS

From the Publisher:             

    

  • Up-to-date, systematic, and in-depth reviews on molecular mechanisms of neurotransmitter release
  • Sufficient background information to suit a broad readership
  • List of comprehensive index words for easy look-up
  • Diagrams and figures in enclosed CD for use in teaching
Within the complex neuronal network of the nervous system, neuron-to-neuron communication occurs mainly through chemical synapses, where the presynaptic nerve terminal releases neurotransmitters that control the function of postsynaptic neurons by acting on postsynaptic receptors.  Recent decades have brought groundbreaking new developments and a wealth of knowledge to this field.  In Molecular Mechanisms of Neurotransmitter Release, leading experts provide concise, up-to-date information on all major molecular mechanisms involved, with complete background information and figures and diagrams to further elucidate key concepts or experiments.

Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release is sure to provide a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for all those who have a general interest in the ever-evolving field of neuroscience.

Content Level Ľ Professional/practitioner

Keywords Ľ Chemical synapses - Endocytosis - Exocytosis - Neurotransmission - Presynaptic receptors

Table of Contents:

1 The Architecture of the Presynaptic Release Site . . . . . . . . . . . . . . . . 1

R. Grace Zhai

2 Multiple Modes of Fusion and Retrieval at the Calyx

of Held Synapse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17

Liming He, Benjamin D. McNeil, and Ling-Gang Wu

3 Roles of SNARE Proteins in Synaptic Vesicle Fusion . . . . . . . . . . . . . 35

Mark T. Palfreyman and Erik M. Jorgensen

4 Roles and Sources of Calcium in Synaptic Exocytosis . . . . . . . . . . . . 61

Zhao-Wen Wang, Bojun Chen, and Qian Ge

5 Regulation of Presynaptic Calcium Channels . . . . . . . . . . . . . . . . . . . 85

Allen W. Chan and Elise F. Stanley

6 Synaptotagmin: Transducing Ca2+-Binding

to Vesicle Fusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107

Carin Loewen and Noreen Reist

7 Functional Interactions Among the SNARE Regulators

UNC-13, Tomosyn, and UNC-18 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135

Robby M. Weimer and Janet E. Richmond

8 Roles of the ELKS/CAST Family and SAD Kinase

in Neurotransmitter Release . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157

Toshihisa Ohtsuka and Yoshimi Takai

9 The Role of Potassium Channels in the Regulation

of Neurotransmitter Release . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171

Laurence O. Trussell and Michael T. Roberts

10 Modulation of Neurotransmitter Release and Presynaptic

Plasticity by Protein Phosphorylation . . . . . . . . . . . . . . . . . . . . . . . . . 187

Zu-Hang Sheng

11 Synaptic Vesicle Endocytosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207

Liesbet Smitz and Patrik Verstreken

12 Lipids and Secretory Vesicle Exocytosis . . . . . . . . . . . . . . . . . . . . . . . . 239

Shona L. Osborne and Frederic A. Meunier

13 Neurotransmitter Reuptake and Synaptic

Vesicle Refilling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263

Richard J. Reimer, Kimberly A. Zaia, and Hiroaki Tani

14 Regulation of Neurotransmitter Release by Presynaptic

Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297

Matthew Frerking and Joyce Wondolowski

15 Transsynaptic Regulation of Presynaptic Release Machinery

in Central Synapses by Cell Adhesion Molecules . . . . . . . . . . . . . . . . 315

Kensuke Futai and Yasunori Hayashi

16 Differential Regulation of Small Clear Vesicles and Large

Dense-Core Vesicles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327

Tao Xu and Pingyong Xu

Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341

 
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